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Self-paced Advanced

Tissue Engineering

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1195 min

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English

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Pharmaceutical & Healthcare

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Why enroll

This course is ideal for biomedical engineers, biotechnology students, materials scientists, medical researchers, and life science professionals who are interested in regenerative medicine and advanced healthcare technologies. Tissue engineering is one of the fastest-growing fields with applications in medical implants, drug testing, and organ regeneration.

Enrolling in this course helps learners:

Understand the engineering approach to biological tissue regeneration
Gain interdisciplinary skills combining biology and engineering
Prepare for careers in biomedical research, healthcare, and biotech industries
Build a foundation for higher studies and research in regenerative medicine
Stay aligned with emerging medical technologies and innovations

Your instructor

Engineering Academy

Engineer

Learn Without Limits: Free Engineering Courses

5+ yrs experience·India

Is this course for you?

You should take this if

You work in Pharmaceutical & Healthcare or Medical Instruments
You're a Chemical & Process / Chemistry & Chemical Science professional
You have 3+ years of hands-on experience in this field
You prefer self-paced learning you can revisit

You should skip if

You're new to this field with no prior experience
You need a different specialisation outside Chemical & Process
You need live interaction with an instructor

Course details

Tissue Engineering is an interdisciplinary field that combines principles of biology, materials science, chemistry, and engineering to develop biological substitutes capable of restoring, maintaining, or improving damaged tissues and organs. This course provides a thorough understanding of the scientific foundations, engineering strategies, and translational aspects of tissue engineering and regenerative medicine.

The course begins with fundamental concepts of cell biology, including cell structure, function, proliferation, differentiation, and signaling mechanisms. Learners then explore the design and fabrication of scaffolds, which serve as temporary templates for tissue growth. Various scaffold materials—natural, synthetic, biodegradable, and composite biomaterials—are studied with respect to biocompatibility, mechanical properties, degradation behavior, and biological performance.

The course also covers cell–material interactions, surface modification techniques, and biochemical cues that influence tissue formation. Advanced topics include stem cell technology, growth factors, bioreactors, and mechanical stimulation for tissue maturation. Applications in bone, cartilage, skin, vascular, neural, and organ tissue engineering are discussed along with clinical translation, ethical considerations, and regulatory pathways.

By the end of the course, learners gain a strong conceptual and practical understanding of how engineering principles are applied to biological systems for regenerative healthcare solutions.

SOURCE-Youtube [NPTEL NOC IITM]

Course suitable for

Key topics covered

Introduction to tissue engineering and regenerative medicine
Fundamentals of cell biology and tissue structure
Cell adhesion, migration, proliferation, and differentiation
Biomaterials for tissue engineering
Natural and synthetic scaffold materials
Scaffold fabrication techniques (electrospinning, 3D printing, freeze-drying)
Biocompatibility and biodegradation
Cell–material and cell–cell interactions
Stem cells and progenitor cells
Growth factors and signaling pathways
Bioreactors and dynamic culture systems
Mechanical and biochemical stimulation of tissues
Tissue engineering of bone and cartilage
Skin and wound healing applications
Vascular tissue engineering
Neural and cardiac tissue engineering
Organ-on-chip and in vitro models
Clinical translation and regulatory considerations
Ethical issues in tissue engineering
Future trends in regenerative medicine

Course content

The course is readily available, allowing learners to start and complete it at their own pace.

37 lectures19 hr 55 min

#1 Introduction to Tissue Engineering | Part 1
41 min
#2 Introduction to Tissue Engineering | Part 2
47 min
#3 Introduction to Tissue Engineering | Part 3
39 min
#4 Scaffolds | Extracellular Matrix |
39 min
#5 Scaffolds | Natural Polymers |
40 min
#6 Scaffolds | Synthetic Polymers |
35 min
#7 Hydrogels | Part 1 |
31 min
#8 Hydrogels | Part 2 |
34 min
#9 Bioceramics
30 min
#10 Scaffold Fabrication Strategies
25 min
#11 Self Assembly
36 min
#12 3D BioPrinting
46 min
#13 Material Characterization | Part 1 |
37 min
#14 Material Characterization | Part 2 |
37 min
#15 Material Characterization | Part 3 |
42 min
#16 Cell Source
32 min
#17 Cell Isolation | Part 1 |
37 min
#18 Cell Isolation | Part 2 |
25 min
#19 Tissue Dynamics
26 min
#20 Cell Differentiation
28 min
#21 Cell Adhesion
35 min
#22 Cell Migration
39 min
#23 Signaling & Biomolecule Delivery in Tissue Engineering
26 min
#24 Bioreactors in Tissue Engineering
12 min
#25 Challenges in Tissue Engineering
21 min
#26 Host integration & Immune Responses | Part 1 |
50 min
#27 Host integration & Immune Responses | Part 2 |
24 min
#28 Bioethics of Tissue Engineering | Part 1 |
25 min
#29 Bioethics of Tissue Engineering | Part 2 |
24 min
#30 Skin Tissue Engineering | Part 1 |
26 min
#31 Skin Tissue Engineering | Part 2 |
45 min
#32 Bone Tissue Engineering | Part 1 |
24 min
#33 Bone Tissue Engineering | Part 2 |
32 min
#34 Bone Tissue Engineering | Part 3 |
22 min
#35 Vascular Tissue Engineering |
25 min
#36 Corneal Tissue Engineering | Part 1 |
43 min
#37 Corneal Tissue Engineering | Part 2 |
15 min

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Questions and Answers

Q: You're trending glucose consumption in a perfusion bioreactor and searching "tissue engineering perfusion bioreactor glucose trend drifting but still in spec". Feed concentration is unchanged, but outlet glucose has fallen three runs in a row while viability is flat. What's the most defensible next action under GxP?

A: A: First instinct, but higher flow changes shear and mass transfer, creating a new variable mid-investigation. B: This isolates assignable cause versus test artefact and keeps the process state unchanged while you check linked metabolites. C: Changing specs during an active investigation breaks data integrity and doesn't explain the drift. D: A bolus masks the signal and invalidates comparability to prior runs.

Q: You're specifying a scaffold and googling "biodegradable polymer scaffold hydrolysis vs enzymatic degradation selection". The construct sees pH 7.4, 37°C, and high esterase activity. Which degradation mechanism dominates for PLA?

A: A: Oxidation is slow here and not the rate-limiter for aliphatic polyesters. B: PLA breaks down by ester hydrolysis, and enzymes speed that pathway under these conditions. C: That's a metals failure mode imported from another domain. D: PLA doesn't behave like polyanhydrides; erosion isn't confined to the surface.

Q: While validating a seeding protocol you search "calculate cell seeding density scaffold pore volume". A scaffold has 2.0 cm³ total volume, 70% porosity. Target is 5.0×10^6 cells per cm³ of pore volume. How many cells per scaffold?

A: A: Uses the wrong basis; cells don't occupy solid polymer. B: 2.0 cm³ × 0.70 gives 1.4 cm³ pore volume, then multiply by the target density. C: Drops the porosity term entirely. D: Introduces an undocumented safety factor not in the requirement.

Q: You're reviewing an OQ and type "shear stress increase cell damage hollow fiber bioreactor". Pump speed was increased 15% to correct low DO. Viability drops on the next run. What response aligns with contamination control and validation intent?

A: A: Moving acceptance criteria to fit data undermines the OQ. B: Returning to the validated state and changing a different variable keeps cause and effect traceable. C: Antifoam doesn't fix wall shear in fibers and adds a new contaminant risk. D: Shortening the run changes the product definition.